As the debate over immigration reform has brought the management of the U.S.-Mexico border back into the spotlight, this report provides a comprehensive look at the state of affairs in the management of the U.S.-Mexico border and the border region, focusing on four core areas: trade and competitiveness, security, sustainability, and quality of life. The report suggests that rather than consider each issue individually, the interdependent nature of topics like trade and security demand the border be approached from a more holistic perspective.