U.S. policy toward Africa has been on autopilot for much of the past four years, following a laundry list of good intentions that established priorities for Africa’s well-being and U.S. security interests. However, a truly sustainable and forward-looking U.S. policy toward Africa should refocus attention on Africa’s opportunity as an economic powerhouse of the future, a strategy that combines both domestic self-interest and an opportunity to help Africa move forward. An emerging landscape of stable economies and growing democratic freedoms in much of Africa is allowing the continent, for the first time, to take advantage of its extensive natural resource endowments, its improving human capital, and its increasing attractiveness to global investors. U.S. policymakers have shown recent signs of understanding Africa’s position and are seeking to strengthen economic relations with African countries. They would be wise to formulate a comprehensive economic policy, not just with interagency coordination, but also in full partnership with the legislative branch, with the private sectors in America and Africa, and with African governments.