Mexican criminal organizations generate billions of dollars in revenues in the United States each year and have developed both sophisticated and low tech ways to “launder” their dirty money and continue trafficking.This paper outlines the use of the economic and financial instruments of national power aimed at degrading transnational criminal organizations in the U.S. and Mexico and increasing their cost of doing business. It will examine the major modes of money laundering employed by the TCOs, describe current U.S. and Mexican anti-money laundering measures, and offer some options for advancing the U.S.-Mexican fight against money laundering.